NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides.
نویسندگان
چکیده
An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 15 شماره
صفحات -
تاریخ انتشار 2014